Serine at a glance

  • Amino acid used in the body’s synthesis of proteins
  • Produced naturally by the body
  • Helps skin retain moisture
  • Supports structures that give skin a more youthful appearance

Serine description

Serine is an amino acid that is used in the body’s synthesis of proteins. It is considered a non-essential amino acid, meaning that it is produced by the body and doesn’t have to be obtained through diet; however, serine production can diminish somewhat over a person’s lifetime. As with all amino acids, serine is valuable in skin care because of its ability to help skin retain moisture, giving it a healthier look and feel. It also supports structures in skin that result in a more youthful appearance. Since serine occurs naturally in the body, it is considered safe as used in cosmetics. It is almost always used in a blend with other ingredients such as phospholipids, electrolyte minerals, and substances found in skin’s natural moisturizing factor (NMF).

Serine references

  • Amino Acids in Nutrition and Health, August 2020, pages 187-199
  • Current Medicinal Chemistry, December 2018, pages 5,512-5,527
  • PLoS ONE, February 2018, ePublication
  • International Journal of Cosmetic Science, August 2009, pages 327-345

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.