Palmitoyl Tetrapeptide-72 Amide



Palmitoyl Tetrapeptide-72 Amide at a glance

  • Synthetic peptide that supports skin’s tensile strength
  • Ongoing use helps maintain a firmer look and feel
  • Encourages foundational organization that lets skin look younger
  • Made from the amino acids alanine, arginine, histidine, and tyrosine

Palmitoyl Tetrapeptide-72 Amide description

Palmitoyl tetrapeptide-72 amide is a synthetic signal peptide made by combining tetrapeptide-72 with a carrier ingredient known as palmitoyl chloride. The building blocks of this peptide are the amino acids alanine, arginine, histidine and tyrosine. Applied to skin, this peptide has clinical data from its supplier indicating that it improves surface firmness and tensile strength. It encourages numerous supportive elements in skin to visibly maintain youthful shape, bounce, and help resist age-related deterioration that results in multiple signs of aging, including first signs of sagging. Think of it as a foundational peptide that provides an organizational framework for skin to look younger. Usage levels of palmitoyl tetrapeptide-72 amide in skin care range from 1–2%, with a smaller portion of this being the peptide itself since the material is supplied as a solution. It’s considered non-irritating and safe for sensitive skin.

Palmitoyl Tetrapeptide-72 Amide references

  • Plastic and Aesthetic Research, January 2021, pages 1–24
  • International Journal of Molecular Sciences, December 2019, pages 1–12
  • UL Prospector, Accessed November 2022

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


We couldn't find this in our ingredient dictionary. We log all missing ingredients and make continuous updates.

Not Rated