Histidine Best Antioxidant Anti-Ageing Soothing Histidine at a glance An amino acid that provides antioxidant benefits Is also capable of soothing skin Alternate name is L-histidine May be animal-derived or synthetic Histidine description Histidine is an amino acid polypeptide that has antioxidant and soothing properties for skin. It is a key building block of the skin protein filaggrin, which plays a leading role in maintaining skin’s barrier. Among the amino acids people need to remain healthy, histidine is considered essential since the body cannot make it so relies on getting this nutrient via proteindine also plays a role in mediating inflammation when skin is injured. Topically, research has shown histidine is a potent scavenger of the hydroxyl radical, which can cause a cascade of damage on skin’s surface. It also plays a role in helping skin maintain hydration by improving its natural moisturizing factors and ability to withstand environmental damage. Interestingly, deficiencies in histidine are one factor behind skin disorders such as atopic dermatitis. Histidine may be animal-derived or synthetic (Paula’s Choice Skincare uses the latter). Usage levels for skin care products range from 0.00009%–0.05%. Its safety for skin has been reviewed and confirmed. You will most often find histidine used with other amino acids since this approach delivers synergistic benefits. Related ingredients: Amino Acids