Matrixyl 3000



Matrixyl 3000 at a glance

  • Trademarked blend that includes two synthetic peptides with anti-aging benefits
  • Proven to reduce wrinkle depth
  • Calms signs of skin irritation
  • Helps mitigate visible skin damage

Matrixyl 3000 description

Matrixyl™ 3000 is a trademarked blend that includes two synthetic peptides: palmitoyl tripeptide-1 (formerly known as palmitoyl oligopeptide) + palmitoyl tetrapeptide-7. These two “messenger” peptides (sometimes referred to as matrikines) work synergistically to send repair signals via skin’s surface that help mitigate visible skin damage and strengthen skin’s supportive elements. Studies have shown ongoing use can lead to a reduction in wrinkle depth. Glycerin, water, butylene glycol, carbomer and polysorbate 20 make up the rest of the Matrixyl™ 3000 blend. Along with smoothing the appearance of wrinkles, Matrixyl™ 3000 has been shown to calm visible signs of sensitisation. The suggested usage concentration of Matrixyl™ 3000 is 3%, although higher or lower amounts may be used depending on the formulary goals. The actual peptide concentration of this blend is much lower than 3% (peptides can work in surprisingly low amounts). Both peptides in Matrixyl™ 3000 have undergone independent safety/toxicology reviews and were deemed safe by the Cosmetic Ingredient Review Expert Panel.

Matrixyl 3000 references

  • Sederma (supplier info), Accessed June 2022, ePublication
  • International Journal of Cosmetic Science, March 2022, pages 232–248
  • International Journal of Toxicology, November 2018, pages 90S-102S
  • Clinical, Cosmetic and Investigational Dermatology, November 2016, pages 411-419
  • Molecular Pharmaceutics, March 2013, pages 1,063-1,069
  • Cosmetic Ingredient Review, August 2012, pages 1-22

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not Rated