Trisodium Ethylenediamine Disuccinate


Chelating Agent

No known benefits

Trisodium Ethylenediamine Disuccinate at a glance

  • Chelating agent which binds with metal ions or metallic compounds
  • Plays a pivotal role in the overall stability, aesthetics, and efficacy of the formulation
  • Commonly used in body washes, cleansers, and shampoos
  • Comes in either solid or granular form as a raw material

Trisodium Ethylenediamine Disuccinate description

Trisodium ethylenediamine disuccinate is a chelating agent which is used in skin care/cosmetic formulations to bind with metal ions or metallic compounds, thereby preventing them from adhering to a surface (such as skin or hair) or causing contamination (as in the case of trace amounts of iron). It is commonly used in body washes, cleansers, and shampoos. As a raw material, trisodium ethylenediamine disuccinate comes in either solid or granular form and is white in color. While chelating agents like trisodium ethylenediamine disuccinate aren’t considered “superstar” ingredients, they play a pivotal role in the product’s overall stability, aesthetics, and efficacy. Such ingredients also help bolster a product’s preservative system by keeping metal ions from destabilizing these essential ingredients in water-based formulas. According to the Cosmetic Ingredient Review (CIR) 2022 report, trisodium ethylenediamine disuccinate is used in 228 formulations (68 leave-on formulations and 160 rinse-off formulations) with a maximum concentration of 0.64% at the time of this writing.

Trisodium Ethylenediamine Disuccinate references

  •, Accessed August 2022, ePublication
  • PubChem, Accessed August 2022, ePublication
  • CIR Report Data Sheet, June 2022, pages 1-18
  • Molecules, July 2018, pages 1–41

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not Rated