Tetrasodium EDTA


Chelating Agent

No known benefits

Tetrasodium EDTA at a glance

  • Prevents minerals and metals in water from bonding to other ingredients
  • Helps prevent unwanted changes to a product’s texture, smell, or consistency
  • A salt form of EDTA (ethylenediamine tetraacetic acid)
  • Is related to disodium and trisodium EDTAs

Tetrasodium EDTA description

Tetrasodium EDTA is a chelating agent used to prevent minerals and metals present in water-based formulations from bonding to other ingredients and impacting their efficacy. Chelating agents also prevent unwanted changes to a product’s texture, odor, and/or consistency, so are considered good stabilizers. Tetrasodium EDTA is one type of salt form of EDTA. The acronym EDTA is short for ethylenediamine tetraacetic acid, a stabilizer used in cosmetics to prevent ingredients in a given formula from binding with trace elements (particularly minerals) that can be present in water in some cases, added separately. Other EDTAs used in cosmetics include disodium and trisodium EDTAs. Tetrasodium EDTA is typically used in amounts of 0.5% or less but is considered safe in cosmetics up to a 2% concentration. Clinical studies have shown it doesn’t penetrate past skin’s surface.

Tetrasodium EDTA references

  • Journal of Applied Polymer Science, April 2021, Volume, Issue 16
  • Advances in Wound Care, June 2015, Volume 4, Number 7, pages 415-421
  • International Journal of Toxicology, January 2002, Issue 21, Supplement 2, pages 95-142

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.