Valine at a glance

  • An essential amino acid that provides hydrating benefits
  • One part of a soothing peptide also made of lysine and proline
  • Works in the body with leucine and isoleucine to synthesize collagens
  • May be animal-derived or synthetic

Valine description

Valine is an amino acid that’s considered essential for health since the body is unable to manufacture it so this amino must be obtained via food or supplements. It may be animal-derived or synthetic, with Paula’s Choice Skincare using the latter form. Valine has soothing properties when combined with amino acids lysine and proline to form a peptide. It works in the body by aiding the synthesis of the skin’s primary collagens, those being 1 and 3. Research hasn’t shown topical application of valine promotes collagen formation, although as with most of the essential aminos, it helps improve skin hydration by improving its natural moisturizing factor (NMF). Usage levels of valine in skin care range from 0.00004%–0.5% in leave-on products, with rinse-off formulas containing up to 1%.

Valine references

  • Bioscience, Biotechnology and Biochemistry, April 2018, pages 611–615
  • Journal of Pharmaceutical Sciences, July 2017, pages 1,814–1,820
  • International Journal of Toxicology, November 2013, pages 41S–64S

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


We couldn't find this in our ingredient dictionary. We log all missing ingredients and make continuous updates.

Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.