Tripeptide-29 at a glance

  • Peptide consisting of amino acids glycine, proline + amino acid derivative hydroxyproline
  • Shown to strengthen skin’s supportive elements
  • Helps improve uneven texture, the look of fine lines, and reverse a dehydrated appearance
  • Small size allows it to penetrate skin’s upper layers more easily

Tripeptide-29 description

Tripeptide-29 is a synthetic, highly purified peptide consisting of amino acids glycine and proline plus amino acid derivative hydroxyproline. Applied to skin, it’s been shown to strengthen skin’s supportive elements. This improves uneven texture and the look of fine lines and also helps reverse a dehydrated appearance. Tripeptide-29’s small size allows it to easily penetrate skin’s uppermost layers so it can reach its target areas sooner. Typical usage level is between 0.1–1%.

Tripeptide-29 references

  • Amino Acids, January 2018, pages 29-38
  • Journal of Cosmetic Dermatology, December 2016, pages 514-519
  • Journal of the Society of Cosmetic Scientists of Korea, 2010, pages 65-69

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.