Tridecapeptide-1 at a glance

  • Synthetic peptide composed of alanine, leucine, lysine and valine
  • Targets the appearance of wrinkles and expression lines
  • Interacts with acetylcholine receptors in skin’s uppermost layers
  • Has clinical data supporting its efficacy on human skin

Tridecapeptide-1 description

Tridecapeptide-1 is a synthetic patented peptide composed of a unique folded and encapsulated combination of the amino acids alanine, leucine, lysine, and valine. It has clinically proven wrinkle-smoothing action that produces visible results within 15 minutes of application. Over time, it’s line-smoothing benefits continue, leading to less visible wrinkles, including around the eyes and mouth. This targeted signal peptide works by influencing acetylcholine receptors within skin’s uppermost layers. Helping to interrupt the process that leads to the appearance of expression lines. It also helps improve rough texture after four weeks of twice-daily use. Recommended usage levels of tridecapeptide-1 range from 1–10% in leave-on skin care products. Clinical data from the supplier has shown this ingredient’s efficacy is improved when paired with glycols used between 2–5%.

Tridecapeptide-1 references

  • The Journal of Clinical and Aesthetic Dermatology, May 2021, pages 14–21
  • Frontiers in Chemistry, October 2020, pages 1–10
  • Scientific Reports, January 2018, pages 1–11
  • Journal of Drugs in Dermatology, September 2016, pages 1,100–1,106

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated