Sodium Acetylated Hyaluronate



Sodium Acetylated Hyaluronate at a glance

  • A derivative of hyaluronic acid
  • Acetyl groups increase bioavailability and stability
  • Hydrates and helps to protect skin from environmental damage
  • Included in cosmetics in percentages between 0.002 and 0.1%

Sodium Acetylated Hyaluronate description

Sodium acetylated hyaluronate is a hydrating, humectant skin care ingredient derived from the NMF (natural moisturizing factor) hyaluronic acid. Sodium acetylated hyaluronate is the acetyl ester of sodium hyaluronate, where some of hyaluronic acid’s hydroxyl groups are replaced with acetyl groups. This swap in groups allows for enhanced bioavailability and better stability, increasing benefits since this allows for penetration deeper into skin and lets the ingredient reach its destination sooner . While hydrating and plumping skin, sodium acetylated hyaluronate also assists in mitigating environmental damage and visibly reducing the appearance of fine lines and wrinkles, making it an interesting ingredient to explore further for its anti-aging properties. It’s most commonly used in leave-on skin care products in percentages between 0.002 and 0.1%. In contrast, “regular” sodium hyaluronate is typically used in higher amounts since more is needed to provide the same benefits.

Sodium Acetylated Hyaluronate references

  • Cosmetic Ingredient Review, October 2022, ePublication
  • Journal of Cosmetic Dermatology, October 2021, pages 2749-2762
  • BioMed Research International, July 2014, ePublication

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated