Sh-Polypeptide-121 at a glance

  • Vegan, collagen-identical peptide made via fermentation
  • Shown to reduce the look of wrinkles and boost skin’s resilience
  • Soothing properties visibly reduce redness and puffiness
  • Excellent synergy with vitamin C

Sh-Polypeptide-121 description

Sh-Polypeptide-121 is bio-identical vegan collagen signal peptide produced via bacterial fermentation. Research from the supplier has shown this single chain peptide can increase skin’s tensile strength by helping to bolster its supportive elements. This also helps smooth the appearance of wrinkles. Sh-polypeptide-121 has excellent synergy with vitamin C, with supplier studies showing the combination leads to a significant improvement in skin’s firm look and feel. It also has soothing properties that may play a role in reducing the appearance of puffy eyes and reddened skin. This peptide is supplied as a solution or a powder. Usage levels vary by format, with the recommended level for the solution being 2% and the more concentrated powder being at 0.1%.

Sh-Polypeptide-121 references

  • Cosmetics, November 2020, pages 1–15
  • Antioxidants, February 2020, pages 1–17
  • Journal of Cosmetic Dermatology, December 2019, pages 1,693–1,699

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated