No known benefits

Schizophyllan at a glance

  • Bio-polymer derived from the thread-like mycelium from which mushrooms grow
  • Helps reduce signs of sensitized skin
  • Hydrating ability is said to surpass hyaluronic acid
  • Supports a firm look and feel

Schizophyllan description

Schizophyllan is a polysaccharide derived from the mycelium of Schyzophyllus commune mushroom, which are the thread-like parts from which they grow. Schizophyllan for skin care is made via fermentation of liquefied mushrooms which are then highly purified. Research has shown that schizophyllan excels at reducing signs of irritated skin. It’s also a good antioxidant, capable of neutralizing damage from airborne pollutants such as smoke. Interestingly, vitamin C (as sodium ascorbyl phosphate) performed better in all-around antioxidant ability when compared to several polysaccharides, including schizophyllan; however, researchers noted its calming ability and suspect it also helps boost skin’s endogenous (naturally occurring) supply of antioxidants. Due to its strong water-binding (humectant) properties, schizophyllan is said to maintain skin’s hydration when under stress better than a similar amount of hyaluronic acid. Of note, more studies are needed to confirm this result. Its antioxidant ability and mild film-forming properties support a firmer look and feel for skin, making schizophyllan a mushroom derivative that can help reduce signs of aging. Usage levels of schizophyllan in skin care range from 0.1–1%, with amounts between 0.1–0.4% being quite effective at improving skin’s hydration, smoothness, and reducing signs of irritation.

Schizophyllan references

  • Skin Pharmacology and Physiology, January 2022, pages 156–165
  • Natural Products and Bioprospecting, August 2019, pages 267–278
  • Cosmetics, July 2016, pages 1–13
  • Mediators of Inflammation, June 2005, pages 63–80

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated