Pentapeptide-59 description

Pentapeptide-59 is a biomimetic (a synthetic ingredient that mimics the processes of a natural ingredient) peptide that contains the amino acids arginine, histidine, phenylalanine and valine. On skin, it has been shown to reduce signs of sensitisation, including visibly reducing redness. It also helps skin become less sensitive by neutralising signals in skin's uppermost layers that would otherwise appear as signs of sensitivity. In order to deliver this peptide to skin and keep it stable during use, it's typically paired with emollient fatty acids such as shea butter or lecithin.

Pentapeptide-59 references

  • Clinical, Cosmetic, and Investigational Dermatology, January 2017, pages 11-16
  • Journal of Biochemistry, February 2017, pages 2,992-3,004
  • The Journal of Biological Chemistry, August 2008, pages 23,914-23,921

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


We couldn't find this in our ingredient dictionary. We log all missing ingredients and make continuous updates.

Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.