Pentapeptide-34 trifluoroacetate



Pentapeptide-34 trifluoroacetate at a glance

  • Synthetic peptide said to help boost skin’s coenzyme Q10 content
  • May help energize skin’s uppermost layers
  • Only low levels needed for documented efficacy
  • Independent research on this peptide is lacking
  • May help protect skin from air polution damage

Pentapeptide-34 trifluoroacetate description

Pentapeptide-34 trifluoroacetate is a colorless synthetic peptide also known as Peptide Q10 Biofunctional. That’s because the supplier of this ingredient claims that topical use helps skin boost its supply of the antioxidant coenzyme Q10, which declines with age. In fact, between the ages of 30–80, epidermal levels of this antioxidant can decline as much as 80%! This peptide may also play a role in helping to energize skin’s surface layers so it looks and feels healthier, with fewer visible lines and wrinkles. The use level of pentapeptide-34 trifluoroacetate in cosmetics is 0.5% when in a water- and propanediol-based blend (meaning the concentration of the peptide is much lower, since these bio-active ingredients typically show efficacy at the parts-per-million level). The lack of independent research supporting the supplier claims on this water-soluble peptide is why it’s not rated as highly as some others in this database; however, there’s no reason to be concerned about using this ingredient, since improving skin’s coenzyme Q10 content can help its surface better withstand environmental exposure. This includes helping to protect skin from certain airborne pollutants.

Pentapeptide-34 trifluoroacetate references

  • Journal of Drugs in Dermatology, December 2020, pages 1,209–1,214
  • Clinical, Cosmetic, and Investigational Dermatology, July 2019, pages 533–544
  • UL Prospector, Accessed August 2023

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.