Palmitoyl Tripeptide-1



Palmitoyl Tripeptide-1 at a glance

  • Helps strengthen skin’s underlying supportive elements
  • Backed by research for minimising the appearance of wrinkles
  • Designated as a “messenger peptide” because of its ability to “tell” skin how to look better
  • Also goes by the names pal-GHK and palmitoyl oligopeptide
  • Safe history of use in cosmetics

Palmitoyl Tripeptide-1 description

Palmitoyl tripeptide-1 is a synthetic fatty acid-linked peptide that can help repair visible skin damage and strengthen skin’s underlying supportive elements. It’s categorise as a “messenger peptide” because of its ability to “tell” skin how to look better, specifically regarding reducing signs of sun damage like wrinkles and rough texture. Some research has shown that this peptide has similar anti-ageing benefits to retinol. (You can use both ingredients for even greater benefits.) Palmitoyl tripeptide-1 also goes by the names pal-GHK and palmitoyl oligopeptide. It appears as a white powder in its raw material form. In 2018, the Cosmetic Ingredient Review Expert Panel looked at personal care products using palmitoyl tripeptide-1 between 0.0000001% to 0.001% and deemed it was safe in current practice of use and concentration. As with most lab-made peptides, a little goes a long way.

Palmitoyl Tripeptide-1 references

  • International Journal of Toxicology, November 2018, pages 90S-102S
  • Cosmetics, May 2017, pages 1-14
  • Experimental and Therapeutic Medicine, August 2016, pages 1,171-1,176
  • International Journal of Cosmetic Science, June 2000, pages 207-218

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not Rated