Palmitoyl Proline Best Humectant Hydration Palmitoyl Proline description Palmitoyl proline combines fatty acid palmitic acid with the amino acid proline. It may be synthetic, animal-derived, or plant-derived (Paula's Choice uses the latter). On skin, palmitoyl proline acts as a surface treatment by contributing a soft feeling. It also helps cosmetic pigments stay blended in a formula. The proline component can help shore up skin's natural supportive elements while the palmitic acid portion prevents moisture loss. Related ingredients: Proline