Palmitoyl Proline



Palmitoyl Proline description

Palmitoyl proline combines fatty acid palmitic acid with the amino acid proline. It may be synthetic, animal-derived, or plant-derived (Paula's Choice uses the latter). On skin, palmitoyl proline acts as a surface treatment by contributing a soft feeling. It also helps cosmetic pigments stay blended in a formula. The proline component can help shore up skin's natural supportive elements while the palmitic acid portion prevents moisture loss.

Palmitoyl Proline references

  • Biointerphases, March 2017, ePublication
  • Amino Acids, June 2012, pages 2,481-2,489

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.