Palmitoyl Pentapeptide-4



Palmitoyl Pentapeptide-4 description

Trade name Matrixyl, a fatty acid mixed with amino acids. Manufactured by the French lab Sederma, it is used primarily as an ingredient in cosmetics making anti-wrinkle claims. Studies both from Sederma and from independent researchers have shown palmitoyl pentapeptide-4 can have an impact on the visual signs of ageing, including fine lines and wrinkles.

Palmitoyl Pentapeptide-4 references

  • Molecular Pharmaceutics, March 2013, pages 1,063-1,069
  • Clinica in Plastic Surgery, July 2011, pages 397-407
  • International Journal of Cosmetic Science, June 2005, pages 155-160

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.