Palmitoyl Oligopeptide



Palmitoyl Oligopeptide description

Synthetic blend of the fatty acid palmitic acid with several amino acids. Also known as pal-KTTKS. Theoretically, many peptides have skin-restoring ability. Palmitoyl oligopeptide was the former catchall name for a handful of peptides, including palmitoyl hexapeptide-12. As more peptides were synthesised for use in skincare, specific names were developed to avoid confusion.

Palmitoyl Oligopeptide references

  • Experimental and Therapeutic Medicine, August 2016, pages 1,171-1,176
  • Journal of Cosmetic Dermatology, June 2015, pages 152-160
  • Biomolecules and Therapeutics, July 2014, pages 321-327

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.