Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine



Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine at a glance

  • A synthetic peptide that supports key proteins in skin
  • Promotes a firmer, less lined look
  • Great synergy with similar signal peptides
  • Made using an amino acid complex and palmitic acid

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine description

Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine is a synthetic signal peptide that helps support specific collagens and proteins found in skin’s dermal-epidermal junction. It also promotes a smoother, less lined skin texture and firmer-feeling surface. This peptide is made by combining the palm-derived fatty acid palmitic acid with the amino acids lysine, valine, and threonine along with diaminobutyric acid, which is a complex amino acid in which some of the hydrogen molecules are replaced by amino groups. In essence, Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine is a complex ingredient! It is used in blends combined with other peptides, in amounts between 1–3%, which puts each peptide in the range clinical data shows is necessary for visible results. In vivo research has shown the synergy of palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine with supporting peptides is what drives its impressive results.

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine references

  • Journal of Cosmetic Dermatology, April 2022, pages 3,458–3,463
  • Maibach, Howard I. and Gorouhi, Farzam. Textbook of Aging Skin, January 2016, pages 1–33
  • Journal of Cosmetic Dermatology, June 2010, pages 108–116

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not Rated