Hydroxypinacolone Retinoate



Hydroxypinacolone Retinoate at a glance

  • Ester of retinoic acid also known as Granactive Retinoid
  • More stable and gentle vitamin A derivative
  • Helps reduce and offset visible signs of aging, like fines lines and wrinkles
  • Is sensitive to light and air

Hydroxypinacolone Retinoate description

Hydroxypinacolone retinoate (HPR) is an ester of retinoic acid and a relatively newer, more stable member of the ever-growing retinoid family, a group of powerhouse vitamin A derivatives that provide skin with potent benefits. Although hydroxypinacolone retinoate might seem like a foreign ingredient name, you’ve probably encountered this ingredient’s trade name, Granactive Retinoid. This type blends 10% HPR with 90% dimethyl isosorbide, a solvent. HPR is a multi-tasking ingredient that communicates with skin by binding to its retinoic acid receptors within skin’s surface layers. Although it connects directly with these receptors, it’s proven to be more gentle than retinoic acid (tretinoin) when applied topically, meaning more reactive and sensitive skin types might want to explore HPR as an alternative to pure retinol. Beyond its comparably gentle nature, research has proven that this retinoic acid ester provides skin both anti-aging and blemish-reducing benefits. Studies show that HPR assisted in reducing the occurrence of mild breakouts as well as the redness associated with them with little disturbance to the skin barrier when combined with retinol glycospheres and papain glycospheres. Those seeking to tackle fine lines and wrinkles as well an uneven tone can also seek out HPR as research has additionally proven this multi-tasking skin care ingredient reduced the appearance of fine lines and wrinkles, as well as improved uneven tone. HPR can positively impact skin at percentages as low as .02%. However, its effectiveness drastically decreases when improperly packaged, such as when kept in jars exposed to light and air. Much like all other vitamin A derivatives and antioxidants, HPR must be kept in air-tight, opaque packaging to remain potent.

Hydroxypinacolone Retinoate references

  • ULProspector, Accessed November 2022, Webpage
  • Journal of Cosmetic Dermatology, November 2020, pages 2350-2358
  • The Journal of Clinical and Aesthetic Dermatology, July 2019, pages E65-E70
  • Italian Journal of Dermatology and Venereology, February 2017, pages 13-17

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


We couldn't find this in our ingredient dictionary. We log all missing ingredients and make continuous updates.

Not Rated