Hexanoyl Dipeptide-3 Norleucine Acetate



Hexanoyl Dipeptide-3 Norleucine Acetate at a glance

  • A synthetic peptide that improves skin surface renewal
  • Has hydrating properties
  • Visibly improves wrinkles
  • Engineered to work specifically in the stratum corneum

Hexanoyl Dipeptide-3 Norleucine Acetate description

Hexanoyl dipeptide-3 norleucine acetate is a synthetic tripeptide that helps skin’s surface (known as the stratum corneum) shed properly plus speed up surface renewal for fresher, more vibrant-looking skin and visibly smoothed wrinkles. The manufacturer has named this peptide “PerfectionPeptide P3” for its ability to refine skin’s appearance by smoothing the surface so it’s better able to reflect light and also maintain hydration. This peptide works by competing with proteins on skin’s surface that, when damaged, can impede exfoliation. It steps in to enhance skin’s ability to shed, and nicely complements the multi-level benefits alpha and beta hydroxy acids provide. In fact, this peptide is stable at a pH of 3.5, which means it can be used in the same formula as exfoliating acids. Hexanoyl dipeptide-3 norleucine acetate has a recommended usage level of 0.5–3%. It’s definitely an intriguing peptide, although there are others that have more substantial research supporting their claims.

Hexanoyl Dipeptide-3 Norleucine Acetate references

  • PubChem, Accessed November 2021, ePublication
  • International Journal for Applied Science, March 2006, pages 1-6

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.