Glucose Oxidase



Glucose Oxidase at a glance

  • Enzyme that catalyses the oxidation of the sugar glucose to gluconic acid
  • Functions as a skin conditioning ingredient
  • Synthesised by fungi and insects and can be manufactured synthetically
  • Has medical and food applications

Glucose Oxidase description

Glucose oxidase is an enzyme that catalyses the oxidation of the sugar glucose to gluconic acid. In nature it is synthesised by several species of fungi and insects such as honeybees. It can also be manufactured synthetically (Paula’s Choice uses this version). In cosmetics, it functions as a skin-conditioning agent. Glucose oxidase is also used in medicine to help monitor glucose levels, and in the food industry to control glucose amounts. The ester of gluconic acid is known as gluconolactone, a polyhydroxy acid (PHA) that in amounts of 2% and up and within the correct pH range has exfoliating properties for skin.

Glucose Oxidase references

  • Molecules, April 2019, pages 1–20
  • Biosensors and Bioelectronics, July 2018, pages 175–179
  • Journal of Clinical and Aesthetic Dermatology, October 2016, pages 50–54
  • Journal of Cosmetic Science, January-February 2013, pages 1–8
  • Journal of Biomaterials Applications, May 2012, pages 917–938
  • Applied Microbiology and Biotechnology, April 2008, pages 927–938

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.