Dipeptide Diaminobutyroyl Benzylamide Diacetate



Dipeptide Diaminobutyroyl Benzylamide Diacetate at a glance

  • Considered a neurotransmitter-inhibiting peptide
  • Also goes by the tradename SYN®-AKE
  • Touted as mimicking the activity of snake venom to paralyze muscles that induce wrinkles
  • More independent studies are needed to validate potential benefits

Dipeptide Diaminobutyroyl Benzylamide Diacetate description

Dipeptide diaminobutyroyl benzylamide diacetate is considered a neurotransmitter-inhibiting peptide, meaning it could have the ability to target expression lines. It also goes by the tradename SYN®-AKE, which nods to the manufacturer’s origin stories of its ability to “mimic the activity of snake venom toxin Waglerin 1.” This is extolled to paralyze muscle contraction related to wrinkles, similar to what injectable procedures can offer—however, it’s important to note that these claims are overexaggerated. While the research regarding dipeptide diaminobutyroyl benzylamide diacetate is alluring, the issue is that these studies are tied back to companies with a financial interest in profiting from this ingredient, so we don’t have reliable independent research to go by at the time of this writing. Is there potential for this ingredient to help minimize expression lines? Possibly, but further independent studies are necessary to validate these findings. Suppliers of dipeptide diaminobutyroyl benzylamide diacetate note that it comes as a white powder in its raw material form. Manufacturers also classify this ingredient as a skin-conditioning agent. Usage levels range from 0.005%–1%.

Dipeptide Diaminobutyroyl Benzylamide Diacetate references

  • UL Prospector (supplier info), Accessed August 2022, ePublication
  • Cosmetics, 2022, pages 1-15
  • Journal of Investigative Dermatology, 2021, page 84

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


We couldn't find this in our ingredient dictionary. We log all missing ingredients and make continuous updates.

Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.