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Dipeptide-2 at a glance

  • A synthetic peptide made by combining tryptophan and valine.
  • May be helpful for alleviating undereye puffiness.
  • Small size allows for sufficient penetration into skin.
  • Tends to be part of blends with other peptides

Dipeptide-2 description

Dipeptide-2 is a small, less complex synthetic peptide made up of the amino acids tryptophan and valine. Studies from one ingredient supplier indicate that this peptide as part of a blend may reduce the look of puffy eyes; however, to date independent research hasn’t supported this claim. Generally, dipeptide-2 is considered a skin conditioning ingredient whose smaller size allows it to easily penetrate skin’s uppermost layers where it can assist with skin renewal and replenishment. For now, that’s the most compelling reason to consider skin care products that contain it. Recommended usage levels on this peptide by itself aren’t available; however, usage levels when this peptide is part of a blend range from 0.5–5%, depending on desired results.

Dipeptide-2 references

  • Cosmetics, November 2020, pages 1–14
  • Experimental and Therapeutic Medicine, August 2016, pages 1,1711,176
  • Bulletin of Experimental Biology and Medicine, May 2015, pages 164-167
  • Amino Acids, June 2012, pages 2,481–2,489; and April 2012, pages 1,379-1,386

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.