Dipalmitoyl Hydroxyproline



Dipalmitoyl Hydroxyproline at a glance

  • An oil-soluble derivative of hydroxyproline
  • Hydroxyproline is the primary amino acid in skin’s collagen
  • Helps preserve skin’s supportive elements
  • The palmitoyl portion comes from hydrating palmitic acid

Dipalmitoyl Hydroxyproline description

Dipalmitoyl hydroxyproline is an oil-soluble version of hydroxyproline, which is the primary amino acid in collagen. Making it oil-soluble improves penetration into skin and lips, where it works to signal skin from the uppermost layers to repair its supportive elements, leading to fewer visible lines and wrinkles. In essence, hydroxyproline is considered a signal peptide. This ingredient works best when paired with oils or glycols since both increase its affinity for skin. Along with supporting skin’s collagen, it also offsets collagen-degrading enzymes known as matrix metalloproteinases. When these enzymes proliferate unchecked, collagen is weakened, leading to signs of sagging and thinning lips. The recommended usage level of dipalmitoyl hydroxyproline is 0.1-2%; clinical studies from suppliers have shown measurable improvement of wrinkle depth when used at 0.5%. Palmitic acid is considered safe for skin, as are proline and hydroxyproline since the latter two are found naturally in skin and its collagen.

Dipalmitoyl Hydroxyproline references

  • International Journal of Toxicology, Volume 36, Supplement 3, November-December 2017, pages 51S-129S
  • International Journal of Cosmetic Science, April 2013, pages 156-162
  • The Journal of Clinical and Aesthetic Dermatology, March 2009, pages 38-43

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not Rated