Arginine/Lysine Polypeptide



Arginine/Lysine Polypeptide at a glance

  • A multi-peptide blend that supports skin’s collagen and elastin
  • Helps offset substances within skin that break down collagen
  • Lab-synthesized for precise, consistent results + stability
  • Topical use helps restore a firmer look and feel

Arginine/Lysine Polypeptide description

Arginine/lysine polypeptide is a lab-synthesized multi-peptide based on the skin-friendly amino acids l-arginine and l-lysine. These amino acids are known as oligopeptides, which are smaller peptide chains of at least two (but not more than 20) amino acids. Studies from the supplier of this ingredient indicate it helps to preserve skin’s natural collagen and elastin by offsetting substances within skin that cause both to degrade over time. Peptides with arginine are considered carrier peptides since they can improve topical delivery of ingredients, while lysine-based peptides generally have signaling qualities. In terms of concentration for visible results, the recommended amount to use is between 0.4-2% of this blend. Since both amino acids making up this peptide are found naturally in skin, arginine/lysine polypeptide is considered safe and non-irritating.

Arginine/Lysine Polypeptide references

  • Journal of Cosmetic Dermatology, December 2016, pages 514-519
  • Amino Acids, August 2011, pages 2,481-2,489
  • International Journal of Cosmetic Science, October 2009, pages 327-345
  • Biochemical and Biophysical Research Communications, August 2006, pages 758-767

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated