Acetylarginyltryptophyl Diphenylglycine



Acetylarginyltryptophyl Diphenylglycine at a glance

  • Synthetically produced cell-communicating tetrapeptide
  • Promotes youthful skin by visibly restoring firmness and curbing sagginess
  • Created through the reaction of acetic acid, arginine, phenylglycine and tryptophan
  • Sold as Relistase® when combined with glycerin

Acetylarginyltryptophyl Diphenylglycine description

Acetylarginyltryptophyl diphenylglycine is a synthetically made tetrapeptide that’s created when acetic acid reacts with the amino acids arginine, phenylglycine and tryptophan. It’s an anti-aging signaling peptide that’s said to help inhibit skin surface enzymes that break down proteins, like collagen. That’s how this tetrapeptide promotes a youthful, firmer look. Acetylarginyltryptophyl diphenylglycine was created by Lipotec S.A.U. and, when combined with glycerin, is sold under the name Relistase®. The recommended usage level is 4% in solution with glycerin, with the peptide itself being a small percentage of this blend (it doesn’t take much of it to help skin).

Acetylarginyltryptophyl Diphenylglycine references

  • ULProspector, accessed July 2022
  • Cosmetics, May 2017, pages 1-14
  • PubChem, March 2014, accessed July 2022

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not Rated