Acetyl Tetrapeptide-9 Best Peptide Anti-Ageing Acetyl Tetrapeptide-9 at a glance “Signal peptide” with anti-aging benefits Supports skin’s firmness and elasticity Touted for hydrating/plumping effects Lab-engineered (synthetic) Acetyl Tetrapeptide-9 description Acetyl tetrapeptide-9 is a “signal peptide” used in skin care for its anti-aging benefits. It works by supporting key skin components like collagen, glycosaminoglycans (GAGs), and lumican, which are essential for maintaining skin structure and elasticity. Studies indicate topical application improves skin density and firmness, for a smoother, more taut appearance. This peptide is also touted for its hydrating and plumping effects. It is lab-engineered through a process known as acetylation (a chemical reaction that involves transforming tetrapeptide-9 into an effective agent for skin). Tetrapeptide-9 is composed of the amino acids aspartic acid, glutamine, histidine and valine. Acetyl tetrapeptide-9 may be found in skin care products under trade names such as Dermican®, Replexium®, and Cosroma® AT-9. The recommended use level ranges from 0.0015%–0.0025% when supplied as a powder, and 1.3–2.1% when supplied in a liquid blend (which equates to the recommended concentration range of the powder form). Note that use levels vary based on the supplier and how much peptide (in parts per million) is added to their blends. Related ingredients: Peptides Glycosaminoglycans Amino Acids