Acetyl sh-Hexapeptide-5 Amide Acetate Best Peptide Anti-Ageing Acetyl sh-Hexapeptide-5 Amide Acetate at a glance Synthetic peptide based on the binding and anchoring protein fibronectin Helps reinforce and maintain skin’s firmness and resilience Topical use improves skin’s tautness and tensile strength Considered non-irritating and non-sensitizing Acetyl sh-Hexapeptide-5 Amide Acetate description Acetyl sh-hexapeptide-5 amide acetate is a synthetic peptide made to be bioidentical to the portion of the fibronectin molecule (a skin-binding and anchoring protein) that contains the amino acids arginine, aspartic acid, proline, and serine. It is also simply called hexapeptide-5. This peptide plays a role in reinforcing skin’s surface resilience, tautness and smoothness, leading to improved tensile strength and a more lifted, firmer appearance. Another benefit of this peptide is that it’s capable of binding water to skin’s surface, offering a hyaluronic acid-like effect on helping skin maintain balanced hydration. Acetyl sh-hexapeptide-5 amide acetate is supplied as a solution with a recommended usage level of 1–3% in skin care formulas. This translates to the peptide level being between 0.04–0.06%, which is why you may see this listed toward the end of a skin care product’s ingredient list. Although an independent safety assessment of this peptide hasn’t been done, validated testing from the supplier has shown it to be non-irritating and non-sensitizing.