Acetyl sh-Hexapeptide-5 Amide Acetate



Acetyl sh-Hexapeptide-5 Amide Acetate at a glance

  • Synthetic peptide based on the binding and anchoring protein fibronectin
  • Helps reinforce and maintain skin’s firmness and resilience
  • Topical use improves skin’s tautness and tensile strength
  • Considered non-irritating and non-sensitizing

Acetyl sh-Hexapeptide-5 Amide Acetate description

Acetyl sh-hexapeptide-5 amide acetate is a synthetic peptide made to be bioidentical to the portion of the fibronectin molecule (a skin-binding and anchoring protein) that contains the amino acids arginine, aspartic acid, proline, and serine. It is also simply called hexapeptide-5. This peptide plays a role in reinforcing skin’s surface resilience, tautness and smoothness, leading to improved tensile strength and a more lifted, firmer appearance. Another benefit of this peptide is that it’s capable of binding water to skin’s surface, offering a hyaluronic acid-like effect on helping skin maintain balanced hydration. Acetyl sh-hexapeptide-5 amide acetate is supplied as a solution with a recommended usage level of 1–3% in skin care formulas. This translates to the peptide level being between 0.04–0.06%, which is why you may see this listed toward the end of a skin care product’s ingredient list. Although an independent safety assessment of this peptide hasn’t been done, validated testing from the supplier has shown it to be non-irritating and non-sensitizing.

Acetyl sh-Hexapeptide-5 Amide Acetate references

  • Journal of Investigative Dermatology, July 2020, pages 1,480–1,483
  • Nano.Micro.Small, June 2007, pages 1,023–1,031
  •, accessed May 2022

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.