Acetyl Hexapeptide-8



Acetyl Hexapeptide-8 at a glance

  • Also known as agireline and acetyl hexpeptide-3
  • Synthetically derived
  • Has water-binding abilities and skin-restoring properties
  • Is considered a neurotransmitter-inhibiting peptide

Acetyl Hexapeptide-8 description

Acetyl hexapeptide-8 is a synthetic peptide that is primarily used in skin care products. Formerly known by its original trade name Argireline and generically as acetyl hexapeptide-3, it has water-binding properties and skin-restoring abilities that play roles in helping skin look and feel younger. Acetyl hexapeptide-8 is a neurotransmitter-inhibiting peptide, meaning it works within skin’s surface layers to interrupt the look of expression lines; however, its efficacy in this regard doesn’t replace in-office wrinkle-smoothing injectable procedures. Interestingly, research from suppliers has shown this peptide also helps support skin’s collagen and preserve a firmer appearance. Studies have shown this peptide can penetrate further into skin and delivery greater efficacy for smoothing expression lines if specific formulary steps are followed, including accounting for the type of emulsion (a higher water content allows greater penetration). As always, this demonstrates the importance of selecting well-formulated skin care products to add to your routine. Acetyl hexapeptide-8 may also be referred to as acetyl hexapeptide-8 amide.

Acetyl Hexapeptide-8 references

  • Cosmetic Ingredient Review, April 2021, pages 1-12
  • Cosmetics, November 2020, Issue 7, Volume 4, page 91
  • La Clinica Terapeutica, November 2020, pages e539-e548
  • Cutaneous and Ocular Toxicology, March 2015, pages 46-52
  • European Journal of Pharmaceutical Sciences, February 2015, pages 27-35
  • Dermatologic Therapy, September-October 2007, issue 5, pages 343-349

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


We couldn't find this in our ingredient dictionary. We log all missing ingredients and make continuous updates.

Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.