Acetyl Hexapeptide-37



Acetyl Hexapeptide-37 at a glance

  • Synthetic peptide
  • Composed of amino acids (alanine, proline, serine, and glycine)
  • Works with water channels in skin’s surface layers
  • Helps provide balanced hydration between skin’s layers

Acetyl Hexapeptide-37 description

Acetyl hexapeptide-37 is a synthetic peptide composed of the amino acids alanine, proline, serine and glycine. This peptide works with the water channels (known as aquaporins) in skin’s surface layers, helping to provide adequate, balanced hydration between skin’s layers, a process which alleviates signs of dry, dehydrated skin. Although there isn’t independent research confirming the effectiveness of this peptide on skin, the supplier (Lipotec) has made the results of their research available in a lengthy technical report that’s supported by third-party studies. Between this information and the wider field of published scientific research on peptides for skin, we feel confident recommending acetyl hexapeptide-37, particularly for dehydrated skin.

Acetyl Hexapeptide-37 references

  • Lipotec, Accessed December 2021, ePublication
  • Phytotherapy Research, December 2019, pages 3,054–3,063
  • Household and Personal Products Industry, September 2013, ePublication

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.