Acetyl Dipeptide-1 Cetyl Ester



Acetyl Dipeptide-1 Cetyl Ester at a glance

  • Lab-made anti-ageing peptide that promotes firmer skin
  • Bio-identical to a skin-natural peptide that aids elasticity
  • Used as part of a blend with butylene glycol and hydroxyethylcellulose
  • Soothing effect offsets stinging and burning sensations on skin

Acetyl Dipeptide-1 Cetyl Ester description

Acetyl dipeptide-1 cetyl ester is a lab-engineered synthetic peptide that combines acetic acid and cetyl alcohol with dipeptide-1, a peptide composed of amino acids arginine and tyrosine. Dipeptide-1 is found naturally in the body and plays a role in maintaining skin’s elasticity. Research has shown that topical application of this peptide protects collagen-making cells known as fibroblasts from the visible impact of glycation, a process in which destructive sugar molecules progressively weaken skin’s supportive elements. This ingredient has also been shown to thwart irritation on skin’s surface that would otherwise result in stinging or burning sensations. As such, it’s a very good option to pair with bio-active ingredients that can be more sensitising for some people. Recommended usage levels of this peptide range from 3–4%; however, since the peptide portion itself is part of a blend, the actual amount of peptide needed to gain benefit is much lower, in the parts per million level. It is considered safe as used in cosmetics.

Acetyl Dipeptide-1 Cetyl Ester references

  • Pharmaceuticals, July 2021, pages 1–22
  • Journal of Cosmetic Dermatology, June 2020, pages 1,415–1,425
  • Journal of the European Academy of Dermatology and Venereology, Supplement 1, February 2016, pages 18–20

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.