Palmitoyl Tripeptide-38


New ingredients

Palmitoyl Tripeptide-38 at a glance

  • Helps skin maintain its structure
  • Visibly improves the appearance of fine lines and wrinkles
  • Helps minimize the look of uneven skin tone and dullness
  • Manufacture under the trade name MATRIXYL synthe’6

Palmitoyl Tripeptide-38 description

An ingredient manufactured by the brand Sederma under the trade name MATRIXYL synthe’6. The only research so far showing this ingredient’s benefit comes from the brand. That research followed 25 women between the ages of 42 to 70 years old who had forehead lines and crow’s feet. After two months, the women reported a decrease in signs of ageing of 31% in some cases, and up to 100% in others using a 2% concentration of MATRIXYL synthe’6 versus the placebo.

Palmitoyl Tripeptide-38 references

  • Journal of Cosmetics, Dermatological Sciences and Applications, September 2021, ePublication
  • Cosmetics, May 2017, ePublication
  • Journal of Cosmetic Dermatology, March 2016, pages 24-30
  • Journal of Drugs in Dermatology, July 2015, pages 699-704
  • Sederma. Matrixyl synthe’ 6. Sederma, Inc. Claim Substantiation Sheet, 2010.

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


We couldn't find this in our ingredient dictionary. We log all missing ingredients and make continuous updates.

Not Rated