Madecassoside description

Madecassoside is of four principal bioactive compounds in the plant extract _Centella asiatica_. One double-blind study has shown even small amounts of this compound (0.1% in one case) combined with vitamin C have antioxidant benefit when applied to skin, and it serves as an antioxidant in its own right. Studies also show it is non-sensitizing and can help revitalise skin’s surface.

Madecassoside references

  • Acta Pharmaceutica, June 2016, pages 233-244
  • Journal of Biochemical and Molecular Toxicology, October 2012, pages 399-406
  • Biotechnology Letters, June 2008, ePublication
  • Planta Medica, June 2008, pages 809-815
  • Experimental Dermatology, May 2008, ePublication

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings


Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.


Necessary to improve a formula's texture, stability, or penetration.


Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.


There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.


May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.


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Not rated